Association Between Oxidative Stress and Anaemia in Pregnancy
DOI:
https://doi.org/10.21276/5vj05t56Keywords:
Oxidative stress, anemia, pregnancyAbstract
Background: Oxidative stress is the topic of interest for most of the researches, as it is associated with the pathogenesis of a number of disorders. Pregnancy though a natural phenomenon is associated with increased susceptibility to oxidative stress. Also, pregnant women are more vulnerable to the nutritional deficiency disorders, most common being iron deficiency anemia. Both oxidative stress and anemia have become a potential threat to both mother and fetus. Therefore, the aim of our study was to determine the association of oxidative stress with anemia in pregnancy. Methods: This study was conducted in Jawahar Lal Nehru Medical College, Aligarh with inclusion of 25 healthy pregnant (Control) and 50 anemic pregnant women. Blood samples were collected and the parameters like Hemoglobin (Hb), malondialdehyde (MDA), Ferritin reducing ability of plasma (FRAP), Total peroxide (TP) and Oxidative stress index (OSI) were estimated. Results: We found that the levels of Hb and FRAP were significantly low and that of MDA, TP and OSI were significantly higher in the anemic pregnant women. Hb was positively correlated with FRAP but negatively with MDA, TP and OSI. The results were statistically significant (p<0.05). Conclusions: Anemia when occurs in disturbs the oxidant- antioxidant balance which further adds to the pre-existing pro-oxidant cellular environment induced by pregnancy. Therefore, in order to prevent both maternal and fetal complications further evaluations are needed.
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References
Qanungo S, Mukherjee M, Ontogenic profile of some antioxidants and lipid peroxidation in human placental and foetal tissues. Mol. Cell Biochem., 2000; 215(1):11-9.
Knapena MFCM, Zuster Zeel PLM, Peters WHM, Steegers EAP. Glutathione and glutathione related enzymes in reproduction: A review. Eur J. obstet-Gynaecol. Reprod biol,1999; 82(2):171-84.
Agrawal A, Gupta S, Sharma RK. Role of oxidative stress in female reproduction. Reprod. Biol. Endocrinol, 2005; 3(1). 28-47.
Tiwari AKM, Maholi AA, Zahra F, Chandyans, Srivastava VK, Negi MPS. Evaluation of oxidative stress and anti-oxidants status in pregnant anemic women. Indian J. Clin. Biochem., 2010; 25(4):411-8.
Khanna A, Dubey M, Sinha R. oxidative stress and its correlation with the severity of maternal anemia. Indian J prev soc med., 2010; 41(3):231-236.
Davidge ST, Hubel CA, Brayden RN, Capeless EC, Mc Laughlin MK. Sera antioxidant activity in uncomplicated and pre-eclamptic pregnancies. Obstetrics and Gynecology, 1992; 79(6): 897-901.
DeMayer EM, Tegman A. Prevalence of anaemia in the World. World Health Organ Qlty 1998; 38(3): 302-16.
Racknagel RD, Ghosal AK. Quantitative estimation of peroxidative degeneration of rat liver microsomal and mitochondrial lipids alter carbon tetrachloride poisoning. Exp Mol Pathol., 1966; 5(suppl 3):413–26.
Iuchi Y, Okada F, Onuma K. Elevated oxidative stress in erythrocytes due to a SOD1 deficiency causes anemia and triggers autoantibody production". Biochem J., 2007; 402(pt2):219- 27.
Schumann K. Safety aspects of iron in food. Ann Nutr Metab., 2001; 45(3): 91-101.
Sanghani SP, Haldankar VA, Shalia KK. Comparative analysis of RBC membrane lipids in thalassemia and iron deficiency anemia in relation to hypochromic and oxidant injury. Indian J Clinical Biochem., 2001; 16(1): 116-21.
Kurtoglu E, Ugur A, Baltaci AK, Undar L. Effect of iron supplementation on oxidative stress and antioxidant status in iron deficiency anemia. Biol Trace Elem Res., 2003; 96(1-3):117-23.
Isler M, Delibas N, Guclu M, Gultekin F, Sutcu R, Bahceci M, et al. Superoxide dismutase and glutathione peroxidase in erythrocytes of patients with iron deficiency anemia: effects of different treatment modalities. Croat Med J., 2002;43(1):16-9.
Rockey DC, Cello JP. Evaluation of the gastrointestinal tract in patients with iron deficiency anemia. N Engl J Med., 1993; 329(23):1691-5.
Benzie II, Strain JJ. Ferric reducing ability of plasma (FRAP) as a measure of antioxidant power: The FRAP assay. Anal Biochem., 1996; 239(1):70-6.
Aslan M, Horoz M, Celik H. Evaluation of oxidative status in iron deficiency anemia through total antioxidant capacity measured using an automated method. Turk J Hematol., 2011; 28(1): 42-6.
Shah AM and Channon VM. Free radicals and redox signaling in cardiovascular disease. Heart, 2004; 90(5): 486-7.
Kumar A, Mahmood T. A Study of Oxidative Stress in Pregnant Anemic Women in Rural Rajasthan. International journal of scientific research, 2015; 4(6):803-5.
Bhale DV, Hivre MD, Mahat RK, Bujurge AA. Study of Malondialdehyde(MDA) as a Marker of Oxidative Stress in Anaemic Pregnant Women. International Journal of Recent Trends in Science and Technology, 2013; 9(1):149-51.
Sujata M, Anitha M, Vishwanath HL, Sreelatha R, Gowda S. Iron and Oxidative Stress in Pregnancy in Anemic Indian Women. Asian J Med Res., 2012; 1(1):149-51.
Halliwell B, Gutteridge JM. Role of free radicals and catalytic metal ions in human disease: an overview. Method in Enzymology, 1990; 186(1): 1-85.
Ishihara M. Studies on lipoperoxide of normal pregnant women and patients with toxemia of pregnancy. Clin chem Acta., 1978; 3(1):1-9.
Patil SB, Kodiwadmath MV, Kodliwadmath SM. Study of oxidative stress and enzymatic antioxidants in normal pregnancy. Indian J Clin Biochem., 2007; 22(1):135-7.
Wayner DD, Burton GW, Ingold KU, Barclay LR, Locke SJ. The relative contributions of vitamin E, urate, ascorbate and proteins to the total peroxyl radical-trapping antioxidant activity of human blood plasma. Biochim Biophys Acta., 1987; 924(3):408-19.
Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem., 2004; 37(2):112-9.
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