Prevalence of Intestinal Metaplasia and Dysplasia in Infectious and Non-infectious Chronic Gastritis
Background: Chronic gastritis is characterized as nearness of incessant mucosal provocative changes driving in the end to mucosal decay and intestinal metaplasia.
Aim: This prospective study was carried out to know the prevalence of Intestinal Metaplasia (IM) in gastric biopsies, and to find out the association between H. pylori, Intestinal metaplasia and dysplasia and to assess the age and sex distribution of the IM in gastric biopsies.
Methods: This prospective study was performed in age group of 26-75 years, attending outpatient Medicine department. A total number of 50 antral gastric biopsies were collected in the department of Pathology and examined histologically to detect intestinal metaplasia. These biopsies were stained by Giemsa to detect H. pylori organisms.
Results: H. pylori was found in n = 23 patients (26-75 years; mean age 48.4). Intestinal metaplasia in general was found in 8 patients. Intestinal metaplasia that is associated with H. pylori seen in n = 6 patients, while intestinal metaplasia without H. pylori seen in n=2 patients. Among intestinal metaplasia 1 case show dysplasia.
Conclusions: This study has revealed that the prevalence of intestinal metaplasia is higher among patients with chronic gastritis and mainly in those patients who are positive for H. pylori with an active chronic gastritis. Intestinal metaplasia mostly affects patients above the age of 45 years.
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