Prevalence of Intestinal Metaplasia and Dysplasia in Infectious and Non-infectious Chronic Gastritis

  • Manoj Saxena Associate Professor, Department of Pathology, G. S Medical College & Hospital, Hapur.
Keywords: Intestinal metaplasia, Chronic gastritis, Dysplasia

Abstract

Background: Chronic gastritis is characterized as nearness of incessant mucosal provocative changes driving in the end to mucosal decay and intestinal metaplasia.

Aim: This prospective study was carried out to know the prevalence of Intestinal Metaplasia (IM) in gastric biopsies, and to find out the association between H. pylori, Intestinal metaplasia and dysplasia and to assess the age and sex distribution of the IM in gastric biopsies.

Methods: This prospective study was performed in age group of 26-75 years, attending outpatient Medicine department. A total number of 50 antral gastric biopsies were collected in the department of Pathology and examined histologically to detect intestinal metaplasia. These biopsies were stained by Giemsa to detect H. pylori organisms.

Results: H. pylori was found in n = 23 patients (26-75 years; mean age 48.4). Intestinal metaplasia in general was found in 8 patients. Intestinal metaplasia that is associated with H. pylori seen in n = 6 patients, while intestinal metaplasia without H. pylori seen in n=2 patients. Among intestinal metaplasia 1 case show dysplasia.

Conclusions: This study has revealed that the prevalence of intestinal metaplasia is higher among patients with chronic gastritis and mainly in those patients who are positive for H. pylori with an active chronic gastritis. Intestinal metaplasia mostly affects patients above the age of 45 years.

 

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References

1. Pelayo Correa, M. Blanca Piazuelo, Keith T. Wilson. Pathology of gastric intestinal metaplasia: clinical implications. Am J Gastroenterol. 2010;105(3):493-8.
2. Marshal BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulcer. Lancet. 1984;1:1311-5.
3. S-J. Tang, R. Wu F Bhaijee. Intestinal metaplasia of the gastric IM is categorized histopathologically into incomplete and complete types. Patients with incomplete IM should undergo endoscopic gastric mapping to define the extent of IM and rule out dysplasia or adenocarcinoma. Stomach. 2013;1(1):187-9.
4. H. Bashar, Mazin Al-Mukhtar. The demonstration of Helicobacter pylori in the gastroduodenal endoscopic biopsies by using different stains. Tikrit Med J. 2004;10(2)1-7.
5. Vinyy Kumar, Abul K. Abbas, Nelson Fausto. Intestinal metaplasia. In: Vinyy Kumar, Abul K. Abbas, Nelson Fausto, eds. Robbins and Cotran Pathologic Basis of Disease. 7th ed. Philadelphia: Saunders; 2004: 813-823.
6. Kang KP, Lee HS, Kim N, Kang HM, Park YS, Lee DH, et al. Role of intestinal metaplasia subtyping in the risk of gastric cancer in Korea. J Gastroenterol Hepatol. 2009;24(1):140-8.
7. International Agency for Research on Cancer. Schistosomes, liver flukes and Helicobacter pylori. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Lyon, France: IARC, World Health Organization; 1994; 61.
8. Correa P, Haenszel W, Cuello C, Tannenbaum S, Archer M. A model for gastric cancer epidemiology. Lancet. 1975;2:58-60.
9. Filipe MI, Munoz N, Matko I, Kato I, Pompe-Kirn V, Jutersek A, et al. Intestinal metaplasia types and the risk of gastric cancer: a cohort study in Slovenia. Int J Cancer. 1994;57:324-9.
10. Morson BC, Sobin LH, Grundmann E, Johansen A, Nagayo T, Serck-Hanssen A. Precancerous conditions and epithelial dysplasia in the stomach. J Clin Pathol. 1980;33:711-21.
11. Carillho C, Modcoicar P, Cunha L, Ismail M, Guissive A, Lorinzoni C, et al. Prevalence of H. pylori, chronic gastritis and intestinal metaplasia in Mozambican dyspeptic patients. Int J Pathol. 2008;4(20):297.
12. Hackelsberger A, Guther T, Schultze V, Labenz J, Roessner A, Malfertheiner P. Prevalence and pattern of H. pylori gastritis in gastric cardia. Am J Gastroenterol. 1997;92(12):2220-4.
Published
2020-09-30
How to Cite
1.
Saxena M. Prevalence of Intestinal Metaplasia and Dysplasia in Infectious and Non-infectious Chronic Gastritis. Int Arch BioMed Clin Res [Internet]. 2020Sep.30 [cited 2020Oct.21];6(3):PA1-PA2. Available from: http://iabcr.org/index.php/iabcr/article/view/609
Section
ORIGINAL ARTICLES ~ Pathology