Vitamin Rich Indian Fruit: Juglans Regia: Effect on Lipid Profile

  • Shah Murad Professor of Pharmacology, at IMDC and DANTH, Islamabad.
  • Seema Saif Gynecology Department, NMC Karachi Pakistan.
  • Dur Muhammad Shaikh Professor of Microbiology at JSMU Karachi Pakistan
  • Jamil Shah Murad Psychologist at Bahria University Karachi Pakistan
  • Abdul Qudoos Arain Assoc Professor of Pharmacology at HBSMDC, Islamabad Pakistan
  • Abdul Ghaffar CWO at DANTH and IMDC Pakistan
  • Sana Tufail Assistant Professor of Pharmacology Shekhzaid Medical College, Rahim yar Khan
Keywords: Juglans Regia, Lipid Profile

Abstract

Background: Hyperlipidemia is one of the important risk factor to develop coronary artery disease (CAD) leading to main cause of morbidity and mortality due to heart attack and cardiac arrhythmias. Decreased level of plasma HDL-cholesterol independently can cause CAD. Recent research studies have proved that walnuts can increase plasma HDL-cholesterol if taken in specific amount per day regularly.

Place and duration of study: Research study was conducted at Lahore General Hospital, Lahore from January 2014 to April 2014.

Methods: Their baseline values of HDL-cholesterol were measured at day-0 and day-60, by separating other lipoprotein fractions using chemical precipitation with Mg2+, then coupling the products of a cholesterol oxidase reaction. Results: In twenty hyperlipidaemic patients, two months of therapy with 30 grams of walnuts per day increase in HDL-cholesterol was 6.3 mg/dl which was a significant change when analyzed biostatistically, showing p-value <0.01. Conclusions: It was concluded from the study, that regular intake of specific amount of walnuts without shell can increase good cholesterol (HDL-cholesterol) in male and female patients of age range from 18 to 65 years.

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References

1. Griel AE, Kris-Etherton PM, Hilpert KF, Zhao G, West SG, Corwin RL. An increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans. Nutr J. 2007;16;6:2.
2. Kelly JH Jr, Sabate J. Nuts and coronary heart disease: an epidemiological perspective. Br J Nutr. 2006;96 Suppl 2:S61-7.
3. R.S. Rosenson, H.B. Brewer Jr., B. Ansell, P. Barter, M.J. Chapman, J.W. Heinecke, A. Kontush, A.R. Tall, N.R. Webb. Translation of high-density lipoprotein function into clinical practice: current prospects and future challenges. Circulation 2013; 128:1256-67.
4. Patel G. Essential fats in walnuts are good for the heart and diabetes. J Am Diet Assoc. 2005;105(7):1096-7.
5. E.M. Degoma, D.J. Rader. Novel HDL-directed pharmacotherapeutic strategies. Nat. Rev. Cardiol. 2011;8:266-77.
6. M. Riwanto, U. Landmesser. High density lipoproteins and endothelial functions: mechanistic insights and alterations in cardiovascular disease. J. Lipid Res. 2013;3227-43.7.
7. Tsai CJ, Leitzmann MF, Hu FB, Willett WC, Giovannucci EL. Frequent nut consumption and decreased risk of cholecystectomy in women. Am J Clin Nutr. 2004;80(1):76-81.
8. Zhao G, Etherton TD, Martin KR, West SG, Gillies PJ, Kris-Etherton PM. Dietary {alpha}-Linolenic Acid Reduces Inflammatory and Lipid Cardiovascular Risk Factors in Hypercholesterolemic Men and Women. J Nutr. 2004;134(11):2991-2997.
9. Anderson K.J.; Teuber S.S.; Gobeille A.; Cremin P.; Waterhouse A.L.; Steinberg F.M. Walnut polyphenolics inhibit in vitro human plasma and LDL oxidation. Journal of Nutrition 2009;131(11):2837-42.
10. Gillen LJ, Tapsell LC, Patch CS, Owen A, Batterham M. Structured dietary advice incorporating walnuts achieves optimal fat and energy balance in patients with type 2 diabetes mellitus. J Am Diet Assoc. 2005;105(7):1087-96.
11. Bes-Rastrollo M, Sabate J, Gomez-Gracia E, Alonso A, Martinez JA, Martinez-Gonzalez MA. Nut consumption and weight gain in a Mediterranean cohort: The SUN study. Obesity 2007;15(1):107-16.
12. Fukuda T, Ito H, Yoshida T. Antioxidative polyphenols from walnuts (Juglans regia L.). Phytochemistry 2003;63(7):795-801.
13. P. Barter. Lessons learned from the Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events (ILLUMINATE) trial. Am. J. Cardiol. 2009;104:10E-15E.
14. Ros E, Nunez I, Perez-Heras A, Serra M, Gilabert R, Casals E, Deulofeu R. A walnut diet improves endothelial function in hypercholesterolemic subjects: a randomized crossover trial. Circulation. 2004; 109(13):1609-14.
15. Blomhoff R, Carlsen MH, Andersen LF, Jacobs DR Jr. Health benefits of nuts: potential role of antioxidants. Br J Nutr. 2006 Nov;96 Suppl 2:S52-60.
16. Tapsell LC, Gillen LJ, Patch CS, Batterham M, Owen A, Bare M, Kennedy M. Including Walnuts in a Low-Fat/Modified-Fat Diet Improves HDL Cholesterol-to-Total Cholesterol Ratios in Patients with Type 2 Diabetes.Diabetes Care. 2004 ;27(12):2777-83.
17. Morgan JM, Horton K, Reese D et al. Effects of walnut consumption as part of a low-fat, low-cholesterol diet on serum cardiovascular risk factors. Int J Vitam Nutr Res 2002; 72(5):341-7.
18. Cortes B, Nunez I, Cofan M, Gilabert R, Perez-Heras A, Casals E, Deulofeu R, Ros E. Acute effects of high-fat meals enriched with walnuts or olive oil on postprandial endothelial function. J Am Coll Cardiol. 2006 17;48(8):1666-71.
19. Marangoni F, Colombo C, Martiello A, Poli A, Paoletti R, Galli C. Levels of the n-3 fatty acid eicosapentaenoic acid in addition to those of alpha linolenic acid are significantly raised in blood lipids by the intake of four walnuts a day in humans. Nutr Metab Cardiovasc Dis. 2006;123(8):2728-41.
Published
2019-12-24
How to Cite
1.
Murad S, Saif S, Shaikh DM, Murad JS, Arain AQ, Ghaffar A, Tufail S. Vitamin Rich Indian Fruit: Juglans Regia: Effect on Lipid Profile. Int Arch BioMed Clin Res [Internet]. 2019Dec.24 [cited 2020Jan.20];5(4):PH9-PH11. Available from: http://iabcr.org/index.php/iabcr/article/view/526
Section
ORIGINAL ARTICLES ~ Pharmacology