Fruits with hypolipidemic and antibacterial activity

Abstract

The irrigation material that commonly used in root canal treatment is sodium hypochlorite, which has certain weaknesses, such as becoming toxic when in contact with periradicular tissue. Sodium hypochlorite is antimicrobial to bacteria, both Gram-positive and negative, spores, fungi, and viruses. However, the optimal property of NaOCl to dissolve organic tissue is non-selective that means it is able to dissolve both necrotic and vital pulp remnants indistinguishably, especially at high concentrations. The in vitro studies showed that 0.5% sodium hypochlorite has a longer incubation time than other irrigation ingredients in eradicating E. faecalis. During the recent decades, awareness towards the role of essential fatty acids in human health and disease prevention has been unremittingly increasing among people. Fish, fish oils and some vegetable oils are rich sources of essential fatty acids. Many studies have positively correlated essential fatty acids with reduction of cardiovascular morbidity and mortality, infant development, cancer prevention, optimal brain and vision functioning, arthritis, hypertension, diabetes mellitus and neurological/neuropsychiatric disorders. Over use of alcohol, enjoying sedentary life, taking junky foods, cigarette smoking are preventable risk factors for Oxidative stress, Coronary Artery Disease, hyperlipidemia, and other heart diseases. Aim of this research was to compare individual and combined effects of Ispaghola and Anjeer in primary as well as secondary hyperlipidemia. It was single blind placebo-controlled research work, conducted from January 2022 to April 2022 at General Hospital, Lahore, Pakistan. One hundred male and female hyperlipidemic patients were selected for research, age range from 20 to 65 years. Inclusion criteria were primary, secondary hyperlipidemic patients. Written and explained consent was taken from all participants and approved by research ethics committee of the hospital. Patients were divided in four equal groups, comprising 25 patients in each group. Their baseline systolic/diastolic blood pressure and lipid profile was estimated and kept in individual’s folder. Group-I was on Ispaghula 10 grams, group-II was on 10 grams Anjeer, and group-III was advised to take 10 grams Ispaghula, and 10 grams Anjeer in combination for 3 months. Group-IV was on placebo therapy. After 3 months when results were compiled and analyzed statistically, it was observed that Ispaghula decreased LDL-c significantly with p-value <0.05, Anjeer decreased LDL-c significantly with p-value <0.01. When both herbs were combinely given, they reduced systolic BP with p-value <0.01, LDL-c reduced highly significantly with p-value <0.001, and HDL-c increased significantly with p-value <0.05. It was concluded from the study that Ispaghula and Anjeer have LDL-c lowering potential if given separately. When used in combination they reduce systolic BP, LDL-c, and increase HDL-c..