Changes in Electrocardiogram Following Percutaneous Coronary Intervention and its Prognostic Implications
DOI:
https://doi.org/10.21276/4r30aa26Keywords:
Biochemical markers, Percutaneous coronary intervention, Risk of myocardial damage, Surface ECGAbstract
Background: The elevation of troponin-T (Trop-t) and creatinine kinase myocardial isoform (Ckmb) and elevation of these markers lead to major adverse cardiac events (MACEs). The association between above-mentioned parameters along with electrocardiogram (ECG) changes can be suitable diagnostic tool for myocardial injury following percutaneous coronary intervention (PCI). The present study was attempted to know the association of the changes in surface ECG and cardiac biomarkers and MACEs following PCI with the outcome in follow up among patients in eastern India. Methods: In present study, 100 patients were randomly selected for coronary angioplasty between April2012 to March2013. All the cases were referred to catheterization laboratory for elective PCI for single vessel or multivessel in native coronary artery. The biomarkers such as trop-t and Ckmb and MACEs along with changes in ECG were estimated as per standard protocol.
Results: ECG changes were statistically significantly correlated with post procedure Trop-t elevation (p<0.001), Ckmb elevation (p<0.001) and MACEs (P<0.01 and p<0.001) in 6 months followed up. Conclusion: In conclusion, the present study showed significant relationship between MACEs during followed up and changed in surface ECG along with Trop-t and Ckmb elevation in the post-PCI period of six-month followed up in stable ischaemic heart disease.
Downloads
References
Schroder R, Dissmann R, Bruggemann T, Wegscheider K, Linderer T, Tebbu U, et al. Extent of early ST-segment elevation resolution: a simple but strong predictor of outcome in patients with acute myocardial infarction. J Am Coll Cardiol. 1994;24:384-391.
Schroder R, Wegscheider K, Schroder K, Dissmann R, Meyer-Sabellek W. Extent of early ST-segment elevation resolution: a strong predictor of outcome in patients with acute myocardial infarction and a sensitive measure to compare thrombolytic regimens: a substudy of the International Joint Efficacy Comparison of Thrombolytics (INJECT) trial. J Am Coll Cardiol. 1995;26:1657-1664.
Van de Werf F, Ardissino D, Betriu A, Cokkinos DV, Falk F, Fox KAA, et al. Management of acute myocardial infarction in patients presenting with ST-segment elevation: the Task Force on the Management of Acute Myocardial Infarction of the European Society of Cardiology. Eur Heart J.
;24:28-66.
Antman EM, Anbe DT, Armstrong PW, Bates ER, Green LA, Hand M, et
al. ACC/AHA guidelines for the management of patients with ST- elevation myocardial infarction: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1999 Guidelines for the Management of Patients with Acute Myocardial Infarction). Circulation. 2004;110:588-636.
Buller CE, Fu Y, Mahaffey KW, Todaro TG, Adams P, Westerhout CM, et al. ST-segment recovery and outcome after primary percutaneous coronary intervention for ST-elevation myocardial infarction. Circulation. 2008;118:1335-1346.
Richardi MJ, Wu E, Davidson CJ, Chor KM, Klocke FJ, Bonow RO, et al. Visualization of discrete microinfarction after percutaneous coronary intervention associated with mild creatine kinase-MB elevation. Circulation. 2001;103:2780-2783.
Selvanayagam JB, Porto I, Channon K, Peterson SE, Francis JM, Neubauer S, et al. Troponin elevation after percuatenous coronary intervention directly represents the extent of irreversible myocardial injury: insights from cardiovascular magnetic resonance imaging. Circulation. 2005;111:1027-1032.
Acharyya M, Haldar SK, Mukhopadhyay D. Assessment of peri- procedural myocardial injury in patients of post-percutaneous coronary intervention: Diagnosis through serum biomarkers as cardiac troponin T and creatine kinase myocardial isoform. International Archives of BioMedical and Clinical Research. 2018;4(1):19-26.
The TIMI Study Group. The Thrombolysis in Myocardial Infarction (TIMI) trial: phase I findings. N Engl J Med. 1985;312:932-936.
BalianV,GalliM,RepettoS,LuviniM,GaldangeloF,CastiglioniB,etal. Intracoronary ST segment shift soon after elective percutaneous coronary intervention accurately predicts periprocedural myocardial injury. Circulation. 2006;114:1948-1954.
Tate JR. Troponin revisited 2008: assay performance. Clin Chem Lab Med. 2008;46(11): 1489-1500.
Giannitsis E, Kurz K, Hallermayer K, Jarausch J, Allan S. Jaffe AS, et al. Analytical validation of a high-sensitivity cardiac troponin T assay. Clin Chem. 2010;56:254-261.
Stein W. Laboratory diagnosis of acute myocardial infarction using CK and CK-MB by inmmunoinhibition. Darmstadt: GIT Verlag, 1988;20-27.
Horder M., Elser RC, Gerhardt W, Mathieu M, Sampson EJ. Approved Recommendation of IFCC Methods for the Measurement of Catalytic Concentration of Enzymes, Part 7 IFCC Method for Creatine Kinase. Eur J Clin Chem Clin Biochem. 1991;29:435-456.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 International Archives of BioMedical and Clinical Research
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors are required to sign and submit the completed “Copyright transfer Form” upon acceptance of publication of the paper. This is determined by a publishing agreement between the author and International Archives of Biomedical and Clinical Research. These rights might include the right to publish, communicate and distribute online. Author(s) retain the copyright of their work. International Archives of Biomedical and Clinical Research supports the need for authors to share, disseminate and maximize the impact of their research.
