Screening of Subclinical Hypothyroidism and Glycosylated Hemoglobin Levels in Healthy Subjects Attending Rural Tertiary Care Centre in Western U.P. (Hapur)
DOI:
https://doi.org/10.21276/fhe8jh85Keywords:
Subclinical Hypothyroidism, Glycosylated Haemoglobin, Serum TSHAbstract
Background: Subclinical hypothyroidism is defined as an elevated serum TSH level and normal concentrations of free T3 (FT3), free T4 (FT4), T3 and T4. A positive association between thyroid and diabetes mellitus is well recognized but to study the effect of thyroid disorders on glucose metabolism in non-diabetic patients is an area for extensive research. Present study was planned to assess correlation between subclinical hypothyroidism and glycosylated hemoglobin levels in non-diabetic patients.
Methods: A case-control study was conducted on total 209 subjects. 109 patients were allotted in case group and 100 in control group. Controls were relatives and friends of patients who were matched for age and sex. Comparison between the case and the control groups were made using Student’s t-test (unpaired) and Box and Whisker Plot and regression graph were presented for correlation between serum TSH and HbA1c.
Results: It was found that there was a positive correlation between the levels of serum TSH (µU/L) and HbA1c (%) in all the participants of the study by Pearson’s correlation coefficient (r=0.35, p < 0.0001).
Conclusion: HbA1c levels are increased in subclinical hypothyroid patients. The effects of the elevated levels of Serum TSH on the HbA1c must be considered when interpreting the HbA1c for the diagnosis of diabetes or prediabetes in the subclinical hypothyroid patients.
Downloads
References
International expert committee report on the role of the A1c assay in the diagnosis of diabetes. Diabetes Carker A, Ogden C, Gunter E, Cogswell M: Unexplained decline in the prevalence of anemia among U.S. children and women between 1988- 1994 and 1999-2002. Am J ClinNutr. 2008;88:1611-1617.
Hsu C, McCulloch C, Curhan G: Iron status and hemoglobin level in chronic renal insufficiency. J Am SocNephrol. 2002;13:2783-2786.
Astor B, Muntner P, Levin A, Eustace J, Coresh J: Association of kidney function with anemia: the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2002;162:1401-1408.
Coresh J, Selvin E, Stevens L, Manzi J, Kusek J, Eggers P, Van Lente F, Levey A: Prevalence of chronic kidney disease in the United States. JAMA. 2007;298:2038-2047.
Saudek C, Herman W, Sacks D, Bergenstal R, Edelman D, Davidson M: A new look at screening and diagnosing diabetes mellitus. J ClinEndocrinolMetab. 2008; 93:2447- 2453.
Iron deficiency--United States, 1999-2000. JAMA 2002; 288:2114- 2116.
Gregg E, Cadwell B, Cheng Y, Cowie C, Williams D, Geiss L, Engelgau M, Vinicor F: Trends in the prevalence and ratio of diagnosed to undiagnosed diabetes according to obesity levels in the U.S. Diabetes Care. 2004; 27:2806- 2812.
Chambers E, Heshka S, Gallagher D, Wang J, Pi-Sunyer F, Pierson Jr. R: Serum iron and body fat distribution in a multiethnic cohort of adults living in New York City. J Am Diet Assoc. 2006;06:680-684.
Trbojevi B. Tiroidnažlezda: Patofiziološkeosnoveiklinikipristup. Beograd. 1998:305–10.
Diez JJ, Iglesias P, Burman KD. Spontaneous normalization of thyrotropinconcentations in patients with subclinical hypothyroidism. J ClinEndocrinolMetab. 2005;90:4124– 27.
Kim MK, Kwon HS, Baek KH, Lee JH, Park WC, Sohn HS, et al. Effects of thyroid hormone on A1C and glycated albumin levels in nondiabetic subjects with overt hypothyroidism. Diabetes Care. 2010;33:2546–48.
Nitin S, Mishra T, Tejinder S, Naresh G. Effect of Iron Deficiency Anaemia on Haemoglobin A1c Levels. Ann Lab Med. 2012;32:17–22. 13. Jen M, Michelle C, Sunil B, Stephen L, Eric S. The Effect of Iron and
Erythropoietin Treatment on the A1C of Patients With Diabetes and
Chronic Kidney Disease. Diabetes Care. 2010;33:2310–13.
Rafat D, Rabbani T, Ahmad J, Ansari M. Influence of iron metabolism indices on HbA1c in non-diabetic pregnant women with and without iron-deficiency anaemia: effect of iron supplementation. Endocrine
Abstracts. 2012;29:550.
Hardikar PS, Joshi SM, Bhat DS, Raut DA, Katre PA, Lubree HG, et al.
Spuriously high prevalence of prediabetes diagnosed by HbA (1c) in young indians partly explained by hematological factors and iron deficiency anaemia. Diabetes Care. 2012;35:797–802.
Koga M, Morita S, Saito H, Mukai M, Kasayama S. Association of erythrocyte indices with glycatedhaemoglobin in premenopausal women. Diabet Med. 2007;24:843–47.
Coban E, Ozdogan M, Timuragaoglu A. Effect of iron deficiency anaemia on the levels of Haemoglobin A1c in nondiabetic patients. ActaHaematol. 2004;112:126–28.
Beciragic A, Bilic-Komarica E. The Importance of HbA1c Control in Patients with Subclinical Hypothyroidism. Mat Soc Med. 2012;24:212– 19.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 International Archives of BioMedical and Clinical Research
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors are required to sign and submit the completed “Copyright transfer Form” upon acceptance of publication of the paper. This is determined by a publishing agreement between the author and International Archives of Biomedical and Clinical Research. These rights might include the right to publish, communicate and distribute online. Author(s) retain the copyright of their work. International Archives of Biomedical and Clinical Research supports the need for authors to share, disseminate and maximize the impact of their research.
