A Comparative Analysis on Safety and Efficacy of Dexmedetomidine, Ketofol, And Propofol for Sedation of Mechanically Ventilated Patients
DOI:
https://doi.org/10.21276/f62x7g08Keywords:
Ketofol, dexmedetomidine, propofol, sedationAbstract
Background: Sleep apnea is becoming a major concern for intensivists because these patients need postoperative admission to the intensive care unit (ICU), mechanical ventilation, and sedation. Dexmedetomidine is a α2-adrenoreceptor agonist. It has analgesic and sedative properties and related with limited respiratory depression. Propofol is a sedative-hypnotic agent with rapid onset and short duration of action. Ketamine binds to opioid and sigma receptors, leading to dissociative anesthesia, amnesia, and analgesia
Methods: We were included total 90 cases. All cases were divided in the three groups (Group A, B & C). Group A was (Ketofol group), Group B (Dexmedetomidine group) & Group C (Propofol group). Each group had 30 cases. This study was conducted in Department of Anesthesia.
Results: RAMSY sedation score was statistically significantly higher in group A than group B at sixth and twelfth h, it was statistically significantly higher in group A than group C in the 1st , 6th and 18th h, it was statistically significantly higher in group B than group C from the first to 24 h.
Conclusion: This study concluded that using Ketofol, Dexmedetomidine or Propofol for sedation of postoperative intubated and mechanically ventilated patients in the surgical ICU for 24 h was effective in maintaining Ramsay sedation score.
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