Study of Sickle Cell Anemia in Tribal Area of Dahod Region of Gujrat
DOI:
https://doi.org/10.21276/hd36bb07Keywords:
Sickle Cell Anemia, HPLC, Tribal Community, ChromatographAbstract
Background: The cross-sectional study was performed to find out the prevalence of sickle cell anemia in tribal population. Methods: This study was conducted in tribal population of Dahod district; Gujrat from November 2018 to September 2019. In this study we screened 1524 tribal subjects comprising adult men & women as well as children in the period of about 11 months. Whole blood Samples were collected in EDTA bulb in different camps organized in PHC & RH centres located in tribal region of Dahod as well as samples were also transported by health workers from these tribal area’s health centres to Biochemistry special investigation laboratory. Samples were analysed by Automated High Performance Liquid Chromatography analyser. Results: We found that 11% of tribal population was having sickle cell trait & 0.5% of were suffering from sickle cell disease. Conclusions: We concluded that in our study in which total 1524 of tribal population was screened for sickle cell anemia by HPLC; 11% of tribal population was found to be affected from sickle cell trait & 0.5% of were suffering from sickle cell disease.
Downloads
References
http://censusindia.gov.in/2011-common/ censusdataonline.html.
Singh KS. Calcutta, India: Anthropological Survey of India; 1992. People of
India: An introduction.
Reich D, Thangaraj K, Patterson N, Prince AL, Singh L. Restructuring
Indian population history. Nature. 2009;461:489-94.
Bhatia HM, Rao VR. Bombay: Institute of Immunohaematology (ICMR);
Genetic atlas of Indian Tribes.
Rao VR. Genetics and epidemiology of sickle cell anemia in India. Indian J
Med Sci. 1988;42:218-22.
Kaur M, Das GP, Verma IC. Sickle cell trait and disease among tribal
communities in Orissa, Madhya Pradesh and Kerala. Indian J Med
Res.1997;55:104-9.
Reich D, Thangaraj K, Patterson N, Prince AL, Singh L. Restructuring
Indian population history. Nature. 2009;461:489-94.
Kate SL, Lingojwar DP. Epidemiology of sickle cell disorder in the state of
Maharashtra. Indian J Hum Genet. 2002;3:161-7.
Serjeant GR, Serjeant BE, editors. Sickle cell disease. 3rd ed. Oxford:
Oxford Univ Press; 2001.
BP Urade ; Sickle Cell Gene (HbS) Scenario in Tribal India ; Urade, J Health
Med Inform 2012, 3:3.
Allison AC (1954) Protection afforded by sickle cell trait against subtertian
malarial infection. Br Med J 1: 290-294.
BP Urade ; Sickle Cell Gene (HbS) Scenario in Tribal India ; Urade, J Health
Med Inform 2012, 3:3
Urade BP (2008) Haemoglobinopathies in Vidarbha region of Maharashtra.
Presented a Paper in a National Conference (March, 7-9, 2008) on
Prevention of Beta-thalassaemia in India, at Anthropological Survey of
India, Head Office, Kolkata.
Lehman H, Cutbush M. Sickle cell cell trait in Southern India. Br Med J
;1:404-405.
Buchi EC. Is sickling a Weddid trait? The Anthropologist 1955;2:25-29.
Ingram VM. Gene mutations in human haemoglobin: the chemical
difference between normal and sickle cell haemoglobin. Nature
;180:326-328.
Odievre MH, Verger E, Silva-Pinto AC, Elion J. Pathophysiological insights
in sickle cell disease. Indian J Med Res. 2011;134:532-7.
Surve RR, Mukherjee MB, Kate SL, Nagtilak SB, Wadia M, Tamankar AA,
et al. Detection of the beta S gene: an evaluation of the solubility test
against automated chromatography and haemoglobin electrophoresis. Br J
Biomed Sci. 2000;57:292-4.
Kulozik AE, Kar BC, Serjeant GR, Serjeant BE, Weatherall DJ. The
molecular basis of alpha thalassemia in India. Its interaction with the sickle
cell gene. Blood. 1988;71:467-72.
Mukherjee MB, Lu CY, Ducrocq R, Gangakhedkar RR, Colah RB, Kadam
MD, et al. The effect of alpha thalassemia on sickle cell anemia linked to
the Arab-Indian haplotype among a tribal and non-tribal population in India.
Am J Hematol. 1997;55:104-9
Mukherjee MB, Surve RR, Ghosh K, Colah RB, Mohanty D. Clinical
diversity of sickle cell disease in western india - influence of genetic
factors.Acta Haematol. 2000;103:122-3.
Daigavane MM, Jena RK, Kar TJ. Perinatal outcome in sickle cell anemia:
A prospective study from India. Hemoglobin. 2013;37:507-15.
Natu N, Khandelwal S, Kumar R, Dave A. Maternal and perinataloutcome
of women with sickle cell disease of a tribal population in central India.
Hemoglobin. 2014;38:91-4.
Colah R, Surve R, Nadkarni A, Gorakshakar A, Phanasgaonkar S, Satoskar
P, et al. Prenatal diagnosis of sickle syndromes in India: Dilemmasin
counseling. Prenat Diagn. 2005;25:345-9.
Colah RB, Gorakshakar AC, Nadkarni AH. Invasive and non-invasive
approaches for prenatal diagnosis of hemoglobinopathies: Experiences
from India. Indian J Med Res. 2011;134:552-60.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 International Archives of BioMedical and Clinical Research
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors are required to sign and submit the completed “Copyright transfer Form” upon acceptance of publication of the paper. This is determined by a publishing agreement between the author and International Archives of Biomedical and Clinical Research. These rights might include the right to publish, communicate and distribute online. Author(s) retain the copyright of their work. International Archives of Biomedical and Clinical Research supports the need for authors to share, disseminate and maximize the impact of their research.
