Assessment of C Reactive Proteins Levels in Hypertensive Patients of Tertiary Care Teaching Hospital in Central India
DOI:
https://doi.org/10.21276/shhhjm04Keywords:
C Reactive proteins, HypertensionAbstract
Background: The present study was conducted for assessing C reactive proteins levels in hypertensive patients
Materials & Methods: The study included 100 hypertension cases and 100 controls who met the inclusion requirements. Data were collected through interview and review of medical records. Newly diagnosed 100 treatment naive cases of Essential Hypertension attending medical OPD and admitted in medical wards was included in the study. Patients diagnosed as hypertensive by physician were enrolled in the study. For each case one control was selected. History of co-morbid illness, prolonged co-morbidity, and history of hypertension was evaluated. All subjects had 5 mL of blood drawn into serum tubes after an overnight fast. After letting the blood clot for 15 minutes at 3000 RPM, the serum was centrifuged out. C-reactive protein levels in the blood were checked right away. CRP levels were evaluated using Immunoturbidimetry. The data was analysed by using descriptive and inferential statistics.
Results: The mean CRP in Cases was more (5.38 ± 1.62) as compared to Controls (1.13 ± 0.48) found statistically significant. (By Un-paired T test; p>0.05). The above table shows association of type (NYHA) of hypertension and CRP among cases. The mean CRP in Stage II was more (6.13 ± 1.28) as compared to Stage I (5.19 ± 1.78) shows statistically significant.
Conclusion: This study confirmed the function of CRP and established its significance as a marker for early detection and prevention of myocardial infarction in hypertensive patients.
Downloads
References
James PA, Oparil S, Carter BL. Evidence-based guideline for the
management of high blood pressure in adults: report from the panel
members appointed to the Eighth Joint National Committee (JNC 8)
JAMA. 2013; 311:507–20.
Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJ. Global and
regional burden of disease and risk factors 2001: System in analysis of
population health data. Lancet 2006; 367:1747‑57.
Fuchs FD, Whelton PK. High blood pressure and cardiovascular
disease. Hypertension. 2020 Feb; 75(2):285-92.
Hajar R. Risk Factors for Coronary Artery Disease: Historical
Perspectives. Heart Views. 2017 Jul-Sep; 18(3):109-114.
Sproston, Nicola R, and Jason J Ashworth. “Role of C-Reactive Protein
at Sites of Inflammation and Infection.” Frontiers in immunology vol. 9
13 Apr. 2018, doi:10.3389/fimmu.2018.00754
Furuhashi M, Saitoh S, Shimamoto K, Miura T. Fatty Acid-Binding
Protein 4 (FABP4): pathophysiological insights and potent clinical
biomarker of metabolic and cardiovascular diseases. Clin Med Insights
Cardiol. 2015;8(Suppl III):23–33.
Giles, Thomas D et al. “Definition and classification of hypertension: an
update.” Journal of clinical hypertension (Greenwich, Conn.) vol. 11,11
(2009): 611-4. doi:10.1111/j.1751-7176.2009.00179.x
Mehri H, Aslanabadi N, Nourazarian A, Shademan B, khaki‑khatibi F.
Evaluation of the serum levels of Mannose binding lectin‑2, tenascin‑C,
and total antioxidant capacity in patients with coronary artery disease.
Journal of Clinical Laboratory Analysis. 2021 Oct; 35(10):e23967.
Keller TT, van Leuven SI, Meuwese MC, Wareham NJ, Luben R, Stroes
ES, Hack CE, Levi M, Khaw KT, Boekholdt SM. Serum levels of
mannose-binding lectin and the risk of future coronary artery disease in
apparently healthy men and women. Arteriosclerosis, Thrombosis, and
Vascular Biology. 2006 Oct 1; 26(10):2345-50.
Sanchís J, Bodí V, Llácer Á, Facila L, Martínez-Brotons Á, Insa L, et al.
Relationship of C-Reactive Protein Levels With Angiographic Findings
and Markers of Necrosis in Non-ST-Segment Elevation Acute Coronary
Syndrome. Rev Esp Cardiol. 2004 May 1; 57(05):382–7.
Tofano, Ricardo Jose et al. “Hypertension, C Reactive Protein and
Metabolic Profile: What is the Scenario in Patients Undergoing
Arteriography?.” Journal of clinical and diagnostic research : JCDR vol.
,8 (2017): BC19-BC23. doi:10.7860/JCDR/2017/26595.10456
Sesso, H. D., Buring, J. E., Rifai, N., Blake, G. J., Gaziano, J. M., &
Ridker, P. M. (2003). C-reactive protein and the risk of developing
hypertension. JAMA, 290(22), 2945–2951.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 International Archives of BioMedical and Clinical Research (IABCR)

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors are required to sign and submit the completed “Copyright transfer Form” upon acceptance of publication of the paper. This is determined by a publishing agreement between the author and International Archives of Biomedical and Clinical Research. These rights might include the right to publish, communicate and distribute online. Author(s) retain the copyright of their work. International Archives of Biomedical and Clinical Research supports the need for authors to share, disseminate and maximize the impact of their research.