Assessment of C Reactive Proteins Levels in Hypertensive Patients of Tertiary Care Teaching Hospital in Central India

Authors

  • Ruchi Khare Research Scholar, Malwanchal University, Indore, Madhya Pradesh, India. Author
  • Shreya Nigoskar Research Supervisor, Professor and Head, Department of Biochemistry, Index Medical College, Hospital and Research Centre, Indore, Madhya Pradesh, India. Author

DOI:

https://doi.org/10.21276/shhhjm04

Keywords:

C Reactive proteins, Hypertension

Abstract

Background: The present study was conducted for assessing C reactive proteins levels in hypertensive patients
Materials & Methods: The study included 100 hypertension cases and 100 controls who met the inclusion requirements. Data were collected through interview and review of medical records. Newly diagnosed 100 treatment naive cases of Essential Hypertension attending medical OPD and admitted in medical wards was included in the study. Patients diagnosed as hypertensive by physician were enrolled in the study. For each case one control was selected. History of co-morbid illness, prolonged co-morbidity, and history of hypertension was evaluated. All subjects had 5 mL of blood drawn into serum tubes after an overnight fast. After letting the blood clot for 15 minutes at 3000 RPM, the serum was centrifuged out. C-reactive protein levels in the blood were checked right away. CRP levels were evaluated using Immunoturbidimetry. The data was analysed by using descriptive and inferential statistics.

Results: The mean CRP in Cases was more (5.38 ± 1.62) as compared to Controls (1.13 ± 0.48) found statistically significant. (By Un-paired T test; p>0.05). The above table shows association of type (NYHA) of hypertension and CRP among cases. The mean CRP in Stage II was more (6.13 ± 1.28) as compared to Stage I (5.19 ± 1.78) shows statistically significant.

Conclusion: This study confirmed the function of CRP and established its significance as a marker for early detection and prevention of myocardial infarction in hypertensive patients.

Downloads

Download data is not yet available.

References

James PA, Oparil S, Carter BL. Evidence-based guideline for the

management of high blood pressure in adults: report from the panel

members appointed to the Eighth Joint National Committee (JNC 8)

JAMA. 2013; 311:507–20.

Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJ. Global and

regional burden of disease and risk factors 2001: System in analysis of

population health data. Lancet 2006; 367:1747‑57.

Fuchs FD, Whelton PK. High blood pressure and cardiovascular

disease. Hypertension. 2020 Feb; 75(2):285-92.

Hajar R. Risk Factors for Coronary Artery Disease: Historical

Perspectives. Heart Views. 2017 Jul-Sep; 18(3):109-114.

Sproston, Nicola R, and Jason J Ashworth. “Role of C-Reactive Protein

at Sites of Inflammation and Infection.” Frontiers in immunology vol. 9

13 Apr. 2018, doi:10.3389/fimmu.2018.00754

Furuhashi M, Saitoh S, Shimamoto K, Miura T. Fatty Acid-Binding

Protein 4 (FABP4): pathophysiological insights and potent clinical

biomarker of metabolic and cardiovascular diseases. Clin Med Insights

Cardiol. 2015;8(Suppl III):23–33.

Giles, Thomas D et al. “Definition and classification of hypertension: an

update.” Journal of clinical hypertension (Greenwich, Conn.) vol. 11,11

(2009): 611-4. doi:10.1111/j.1751-7176.2009.00179.x

Mehri H, Aslanabadi N, Nourazarian A, Shademan B, khaki‑khatibi F.

Evaluation of the serum levels of Mannose binding lectin‑2, tenascin‑C,

and total antioxidant capacity in patients with coronary artery disease.

Journal of Clinical Laboratory Analysis. 2021 Oct; 35(10):e23967.

Keller TT, van Leuven SI, Meuwese MC, Wareham NJ, Luben R, Stroes

ES, Hack CE, Levi M, Khaw KT, Boekholdt SM. Serum levels of

mannose-binding lectin and the risk of future coronary artery disease in

apparently healthy men and women. Arteriosclerosis, Thrombosis, and

Vascular Biology. 2006 Oct 1; 26(10):2345-50.

Sanchís J, Bodí V, Llácer Á, Facila L, Martínez-Brotons Á, Insa L, et al.

Relationship of C-Reactive Protein Levels With Angiographic Findings

and Markers of Necrosis in Non-ST-Segment Elevation Acute Coronary

Syndrome. Rev Esp Cardiol. 2004 May 1; 57(05):382–7.

Tofano, Ricardo Jose et al. “Hypertension, C Reactive Protein and

Metabolic Profile: What is the Scenario in Patients Undergoing

Arteriography?.” Journal of clinical and diagnostic research : JCDR vol.

,8 (2017): BC19-BC23. doi:10.7860/JCDR/2017/26595.10456

Sesso, H. D., Buring, J. E., Rifai, N., Blake, G. J., Gaziano, J. M., &

Ridker, P. M. (2003). C-reactive protein and the risk of developing

hypertension. JAMA, 290(22), 2945–2951.

https://doi.org/10.1001/jama.290.22.2945

Downloads

Published

12.06.2023

Issue

Section

ORIGINAL ARTICLES ~ Biochemistry

Similar Articles

1-10 of 57

You may also start an advanced similarity search for this article.