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Use of Nifedipine and Isoxpurine Hydrochloride in Prevention of Preterm Labor: A Prospective and Comparative study
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January - March 2017 | Vol 3 | Issue 1 | Page : 47-49

Manju Kumari

Professor, Department of Obstetrics and Gynaecology, Mahavir Institute of Medical Sciences, Vikarabad, R. R Dist.

How to cite this article: Kumari M. Use of Nifedipine and Isoxpurine Hydrochloride in Prevention of Preterm Labor: A Prospective and Comparative study. Int Arch BioMed Clin Res. 2017;3(1):47-49.DOI:10.21276/iabcr.2017.3.1.13


Background: The study was done in Obstetric & Gynaecology Department of Dr. VRK Women's Medical college to prevent the preterm labor which one is better either Nifedipine or Isoxpurine hydrochloride. Methods: In one month period total 1884 patients attended OPD of Obstetric & Gynaecology. Out of 416 patients came with preterm labor.200 patients chosen for tocolysis.100 patients were given Nifedipine and 100 patients Isoxpurine hydrochloride. Results: Preterm labor incidence was 22% while preterm delivery incidence was 20.9%. Nifedipine was more effective than Isoxpurine hydrochloride for preterm labor whether it is diagnosed either in early stage or late stage. In early-diagnosed preterm labor, Nifedipine had higher efficacy than Isoxpurine (P value 6.45 × 10?6) and also higher efficacy than its own in late diagnosed preterm labor (P value 2.08 × 10?5). Conclusions: In India preterm labor incidence is very high. So Nifedipine is better option than Isoxpurine hydrochloride especially when patient is having early signs of preterm labor.

Keywords: Uterine contractions, Betamethasone, prematurity, nifedepine, isoxpurine, preterm labor

  1. Martin JA, Kochank KD, Strobino DM, et al. Annual summary of vital statistics 2003. Pediatrics. 2005;115:619–639. doi: 10.1542/peds.2004-2695. [PubMed] [Cross Ref]
  2. Begum F, Buckshee K, Pande JN. Risk factors associated with preterm labor. Bangladesh Med Ras Coune Bull. 2003;29:59–66. [PubMed]
  3. Bibby E, Stewart A. The epidemiology of preterm birth. Neuro Endocrinol Lett. 2004;25:43–47. [PubMed]
  4. Shingairai AF, Siaban DH, Godfrey BW. Risk factors for prematurity at Harare maternity hospital, Zimbabwe. Int J Epidemiol. 2004;33:1194–1201. doi: 10.1093/ije/dyh120. [PubMed] [Cross Ref]
  5. King JF, Flenady VJ, Papatsonis DNM et al. Calcium channel blockers for inhibiting preterm labor (cochrane review). The cochrane library. Chichester: Wiley; 2004.
  6. RCOG. Tocolytic drugs for women in preterm labor. In: Clinical guideline no. I (B). London: RCOG Press; 2002.

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